The NACHC Community Health Institute (CHI) and EXPO is the largest annual gathering of health center clinicians, executives, consumer board members, along with State/Regional Primary Care Associations and Health Center Controlled Networks. The conference (August 27-29) is scheduled to kick off in San Diego, CA, at a time when health centers are charting a new course in a rapidly changing health environment and being called upon to assume a larger role in the nation’s health care system. Health centers now confront a time when change must be viewed within the context of opportunity. They must find new ways to deliver care more effectively and efficiently. The pathway to sustainability and competition calls for training in new disciplines, collaboration, workforce development, technology and pursuing innovative models of care that target both the social determinants of health and address the emerging public health issues and challenges of our day.